• James Lewis , Australian football (soccer) referee in the A-League
• James Lewis (1840?1896), American comedian from New York
• James A. Lewis (1933?1997), United States Libertarian Party 1984 Vice-Presidential candidate
• James Paul Lewis, Jr., operated one of the largest and longest running "Ponzi schemes" in United States history
• James R. Lewis, professional writer and academic specializing in new religious movements and New Age
• James T. Lewis (1819?1904), Governor of Wisconsin from 1864 to 1866
• James W. Lewis, American convicted in relation to the 1982 Tylenol scare
• J. Hamilton Lewis (1863?1939), United States Senator
• James "Jimmy" Lewis, fictional character from video game Rage of the Dragons

See also

• Jim Lewis
• Lewis